Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.
Identifieur interne : 003C73 ( Main/Exploration ); précédent : 003C72; suivant : 003C74Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.
Auteurs : RBID : pubmed:10048733English descriptors
- KwdEn :
- Adult, Aged, Antigens, Surface (metabolism), Enzyme-Linked Immunosorbent Assay, Feces (chemistry), Feces (cytology), Female, Granulocytes (cytology), Granulocytes (metabolism), Humans, Indium Radioisotopes (metabolism), Inflammatory Bowel Diseases (metabolism), Inflammatory Bowel Diseases (pathology), Leukocyte L1 Antigen Complex, Male, Membrane Glycoproteins (metabolism), Middle Aged, Neural Cell Adhesion Molecules (metabolism), Time Factors.
- MESH :
- chemical , metabolism : Antigens, Surface, Indium Radioisotopes, Membrane Glycoproteins, Neural Cell Adhesion Molecules.
- chemistry : Feces.
- cytology : Feces, Granulocytes.
- metabolism : Granulocytes, Inflammatory Bowel Diseases.
- pathology : Inflammatory Bowel Diseases.
- Adult, Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Leukocyte L1 Antigen Complex, Male, Middle Aged, Time Factors.
Abstract
Several studies have suggested that clinical indices of disease activity in inflammatory bowel disease (IBD) do not adequately reflect the degree of inflammation in most such patients. Faecal excretion of indium-111-labelled neutrophilic granulocytes has been suggested as the gold standard of disease activity, but its complexity and high cost and the exposure of patients to ionizing irradiation have limited the use of this technique. The aim of this study was to investigate the correlation between the faecal excretion of the granulocyte marker protein calprotectin and that of 111In-labelled granulocytes.
PubMed: 10048733
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.</title><author><name sortKey="R Seth, A G" uniqKey="R Seth A">A G Røseth</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Medicine, Aker University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Dept. of Medicine, Aker University Hospital, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, P N" uniqKey="Schmidt P">P N Schmidt</name></author><author><name sortKey="Fagerhol, M K" uniqKey="Fagerhol M">M K Fagerhol</name></author></titleStmt><publicationStmt><date when="1999">1999</date><idno type="RBID">pubmed:10048733</idno><idno type="pmid">10048733</idno><idno type="wicri:Area/Main/Corpus">003F48</idno><idno type="wicri:Area/Main/Curation">003F48</idno><idno type="wicri:Area/Main/Exploration">003C73</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antigens, Surface (metabolism)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Feces (chemistry)</term><term>Feces (cytology)</term><term>Female</term><term>Granulocytes (cytology)</term><term>Granulocytes (metabolism)</term><term>Humans</term><term>Indium Radioisotopes (metabolism)</term><term>Inflammatory Bowel Diseases (metabolism)</term><term>Inflammatory Bowel Diseases (pathology)</term><term>Leukocyte L1 Antigen Complex</term><term>Male</term><term>Membrane Glycoproteins (metabolism)</term><term>Middle Aged</term><term>Neural Cell Adhesion Molecules (metabolism)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Surface</term><term>Indium Radioisotopes</term><term>Membrane Glycoproteins</term><term>Neural Cell Adhesion Molecules</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Feces</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Feces</term><term>Granulocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Granulocytes</term><term>Inflammatory Bowel Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammatory Bowel Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Leukocyte L1 Antigen Complex</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have suggested that clinical indices of disease activity in inflammatory bowel disease (IBD) do not adequately reflect the degree of inflammation in most such patients. Faecal excretion of indium-111-labelled neutrophilic granulocytes has been suggested as the gold standard of disease activity, but its complexity and high cost and the exposure of patients to ionizing irradiation have limited the use of this technique. The aim of this study was to investigate the correlation between the faecal excretion of the granulocyte marker protein calprotectin and that of 111In-labelled granulocytes.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10048733</PMID><DateCreated><Year>1999</Year><Month>07</Month><Day>14</Day></DateCreated><DateCompleted><Year>1999</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0036-5521</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Scandinavian journal of gastroenterology</Title><ISOAbbreviation>Scand. J. Gastroenterol.</ISOAbbreviation></Journal><ArticleTitle>Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.</ArticleTitle><Pagination><MedlinePgn>50-4</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several studies have suggested that clinical indices of disease activity in inflammatory bowel disease (IBD) do not adequately reflect the degree of inflammation in most such patients. Faecal excretion of indium-111-labelled neutrophilic granulocytes has been suggested as the gold standard of disease activity, but its complexity and high cost and the exposure of patients to ionizing irradiation have limited the use of this technique. The aim of this study was to investigate the correlation between the faecal excretion of the granulocyte marker protein calprotectin and that of 111In-labelled granulocytes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Calprotectin in stool extracts from 19 patients with Crohn's disease (CD), 10 with ulcerative colitis (UC), and 9 presumably healthy controls was assessed with a simple enzyme-linked immunosorbent assay. Simultaneously, the faecal excretion of autologous 111In-labelled granulocytes was measured.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was a strong correlation between the average daily excretion of calprotectin and that of the total 3-day excretion of 111In-labelled granulocytes (r = 0.87, P < 0.0001). Furthermore, the concentration of calprotectin, assessed in a small stool sample on day 1, also correlated well with the excretion 111In-labelled granulocytes (r = 0.80, P < 0.0001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results suggest that faecal calprotectin reflects the granulocyte migration through the gut wall in patients with IBD and hence might serve as a simple, inexpensive alternative to the indium-111 technique.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Røseth</LastName><ForeName>A G</ForeName><Initials>AG</Initials><Affiliation>Dept. of Medicine, Aker University Hospital, Oslo, Norway.</Affiliation></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>P N</ForeName><Initials>PN</Initials></Author><Author ValidYN="Y"><LastName>Fagerhol</LastName><ForeName>M K</ForeName><Initials>MK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>NORWAY</Country><MedlineTA>Scand J Gastroenterol</MedlineTA><NlmUniqueID>0060105</NlmUniqueID><ISSNLinking>0036-5521</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antigens, Surface</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Leukocyte L1 Antigen Complex</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Neural Cell Adhesion Molecules</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antigens, Surface</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Feces</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Granulocytes</DescriptorName><QualifierName MajorTopicYN="Y">cytology</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Inflammatory Bowel Diseases</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Leukocyte L1 Antigen Complex</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neural Cell Adhesion Molecules</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>2</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>2</Month><Day>27</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>2</Month><Day>27</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10048733</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:10048733
|texte= Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10048733" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |